Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 4, No. 8, 1976, pp.1331-1335
Published online, 1st January, 1970
DOI: 10.3987/R-1976-08-1331
A New Alkylation of Pyridazines with Nitromethane and Nitroethane

Mitsuji Yanai,* Shigeko Takeda, and Makoto Nishikawa

*Faculty of Pharmaceutical Sciences, Nagasaki University, 1-14, Bunkyo-machi, Nagasaki 852-8521, Japan

Abstract

3-Hydroxy-4-ethoxycarbonyl-6-chloropyridazine (I) reacts with nitromethane and nitroethane to give the respective 5-methyl (I-A) and 5-ethyl (I-B) derivatives when their solution in DMSO is stirred at room temperatures in the presence of potassium carbonate. The scope of this type of nuclear alkylation of pyridazines is rather wide as shown in Table.