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Communication | Regular issue | Vol 4, No. 8, 1976, pp.1377-1385
Published online, 1st January, 1970
DOI: 10.3987/R-1976-08-1377
Studies on the Synthesis of Bisindole Alkaloids. VI. Novel Lactam Derivatives in the Vinblastine Series

James P. Kutney,* John Balsevich, and Gordon H. Bokelman

*Department of Chemisry, University of British Columbia, Vancouver 8, V5T 1W5 , Canada


The utilization of osmium tetroxide as an oxidant can provide a synthetic entry into lactam derivatives in the bisindole area. In complimentary investigations it was shown that iodine and air oxidation of a series of bisindole alkaloids can also provide some novel lactam derivatives. These substances are important for the purpose of biological evaluation as potential anti-tumor agents and, in particular, for information relating to structure-activity relationships in the clinically important vinblastine family of alkaloids.