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Report | Regular issue | Vol 4, No. 10, 1976, pp.1699-1706
Published online, 1st January, 1970
DOI: 10.3987/R-1976-10-1699
Semisynthetic β-Lactam Antibiotics. III. Synthesis and Antibacterial Activity of α-(2-Imidazolinylamino)benzylpenicillin and -desacetoxycephalosporin

Mario Pinza,* Giuseppe LiBassi, Giampietro Broccali, and Giorgio Pifferi

*Laboratories for Biomedical Research, ISF, Trezzano s/N, Milan, Italy

Abstract

The preparation of the new β-lactam antibiotics α-(2-imidazolinylamino)benzyl-penicilline in (I) and -desacetoxyccphalosporin (II) via the appropriate phenylacetylchloride hydrochloride (VII) is reported. Their antibacterial activities against several micro-organisms have been determined in vitro.