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Report | Regular issue | Vol 4, No. 10, 1976, pp.1707-1710
Published online, 1st January, 1970
DOI: 10.3987/R-1976-10-1707
Pyrimidone Derivatives as Effective Acid Captors. A Method for the Preparation of Carboxamides

Edward Bald, Susumu Kobayashi, and Teruaki Mukaiyama*

*Faculty of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan

Abstract

The equimolar reactions of carboxylic acids and amines with 1-methyl-2-chloropyridinium salt in the presence of 3,4-dihydro-9-methyl-2H-pyrido[1,2-a]pyrimidin-2-one(II) or 3,4-dihydro-3,9-dimethyl-2H-pyrido[1,2-a]pyrimidin-2-one (III) afforded the corresponding carboxamides in high yields.