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Communication | Regular issue | Vol 6, No. 4, 1977, pp.443-448
Published online, 1st January, 1970
DOI: 10.3987/R-1977-04-0443
Studies on the Synthesis of Bisindole Alkaloids. X. The Synthesis of Novel Vinblastine Derivatives

James P. Kutney,* William B. Evans, and Toshio Honda

*Department of Chemisry, University of British Columbia, Vancouver 8, V5T 1W5, Canada


The coupling of catharanthine-Nb-oxide with various novel vindoline derivatives provides a series of novel vinblastine derivatives. These compounds provide an opportunity to evaluate the importance of the functionality in the dihydroindole unit of the bisindole system in terms of anti-tumor activity.