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Communication | Regular issue | Vol 6, No. 8, 1977, pp.1119-1124
Published online, 1st January, 1970
DOI: 10.3987/R-1977-08-1119
Synthesis of N-Substituted Isoquinolones. Model for the Biosynthesis of Isoquinolone Alkaloids

Somsak Ruchirawat,* Ukrit Borvornvinyanant, Kesra Hantawong, and Yodhathai Thebtaranonth

*Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand

Abstract

Reactions of enamine intermediate (II) derived from 1-benzylisoquinoline derivative (I) with cuprous chloride/oxygen or singlet oxygen gave isoquinolone derivative (III). The implication of the reaction of enamine intermediate with singlet oxygen to the biosynthesis of isoquinolone alkaloid is discussed.