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Communication | Regular issue | Vol 9, No. 1, 1978, pp.1-6
Published online, 1st January, 1970
DOI: 10.3987/R-1978-01-0001
Polymethoxylated Ioquinokines as Potential Antimitotic Agents

Maria Iorio, Arnold Brossi,* and Colin F. Chignell

*Laboratory of Chemical Diseases, National Institute of Diabetes and Digestive and Kidney, National Institute of Health, Bethesda, MD 20892, U.S.A.

Abstract

Several polymethoxylated isoquinolines related to the alkaloids sendaverine and cryptostyline III have been prepared from mescaline. Using colchicine as a standard none of these compounds did show any binding affinity to the rat brain microtubule protein.