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Communication | Regular issue | Vol 9, No. 12, 1978, pp.1729-1732
Published online, 1st January, 1970
DOI: 10.3987/R-1978-12-1729
■ Reaction of o-Aminobenzamide Derivatives with Ethyl 3-Ethoxymethylene-2,4-dioxovalerate. Synthesis of Pyrrolo[1,2-a]quinazoline-1,5-diones

Takushi Kurihara* and Yasuhiko Sakamoto

*Faculty of Pharmaceutical Science, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan

Abstract

Reaction of ethyl 3-ethoxymethylene-2,4-dioxovalerate (1) with o-aminobenzamide derivatives gave 3-aminomethylene derivatives (4a,b and 5a), which were subsequently refluxed in ethanol to give rise to a mixture of pyrrolo[l,2-a]quinazoline-1,5-diones (6a,b and 7a) and 3,4-dihydro-4-oxoquinazoline analogue (8a,b and 9a) in moderate yields, respectively.