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Communication | Regular issue | Vol 9, No. 12, 1978, pp.1733-1739
Published online, 1st January, 1970
DOI: 10.3987/R-1978-12-1733
Studies of Pyrazines. II. Synthetic Study of Hydroxypyrazine

Takeo Konakahara* and Yukio Takagi

*Department of Industrial Chemistry, Faculty of Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278-8510, Japan


The effects of a reaction temperature and an alkali-addition velocity on the yield of hydroxypyrazine in the condensation of glycine amide hydrochloride with glyoxal, were discussed. The lower the reaction temperature, the higher was the yield of hydroxypyrazine, unless the reaction mixture was solidified. The effect of the alkali-addition velocity on the yield of the product was like that of pH on the rate of Shiff-base formation reaction, which shows a maximum value.