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Report | Regular issue | Vol 12, No. 5, 1979, pp.691-694
Published online, 1st January, 1970
DOI: 10.3987/R-1979-05-0691
A New Synthesis of 5-Aryl-5-deazaflavins [5-Arylpyrimido[4,5-b]quinoline-2,4(3H,10H)-diones]

Fumio Yoneda,* Toshiko Asano, Kinshiro Tsukuda, and Akira Koshiro

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan

Abstract

The condensation of 6-(N-alkylanilino)-3-methyluracils with aryl aldehydes in the presence of polyphosphoric acid afforded the corresponding 5-aryl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-diones (5-aryl-3-methyl-5-deazaflavins) in a single step and in high yields. These compounds were reduced to the corresponding 5-aryl-1,5-dihydro-5-deazaflavins by ethanolic potassium hydroxide.