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Communication | Regular issue | Vol 12, No. 8, 1979, pp.1009-1011
Published online, 1st January, 1970
DOI: 10.3987/R-1979-08-1009
■ Novel Convenient Synthesis of 1,4-Diazepines; 6-Alkoxy-5,6-dihydro-4H-pyrrolo[1,2-a]thieno[3,2-f]-1,4-diazepine-4-ones

S. Rault, M. Cugnon de Sévricourt, and M. Robba*

*Centre d’Etudes et de Recherche sur le Médicament de Normandie, U. F. R. des Sciences Pharmaceutiques, Université de Caen, 1, rue Vaubénard, 14032 Caen Cedex, France

Abstract

Cyclisation of N-(3-cyano-2-thienyl)-2-formyl pyrrole with alcohols in sodium hydroxide solution resulted in the formation of the corresponding 6-alkoxy-5,6-dihydro-4H-pyrrolo[1,2-a]thieno[3,2-f]-1,4-diazepine-4-ones.