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Communication | Regular issue | Vol 12, No. 10, 1979, pp.1297-1299
Published online, 1st January, 1970
DOI: 10.3987/R-1979-10-1297
Synthesis of 3-Hydroxy-5-methylisoxazole and 5-Substituted 4-Oxazolin-2-one

Hiroshi Fukumi,* Kazuhiko Oohata, and Kazuo Takada

*Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan


An improved synthesis of 3-hydroxy-5-methylisoxazole and some rearrangements of O-benzoyl β-keto-propionohydroxamates with the formation of 5-substituted 4-oxazolin-2-one are described.