Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Review | Regular issue | Vol 12, No. 10, 1979, pp.1343-1368
Published online, 1st January, 1970
DOI: 10.3987/R-1979-10-1343
Synthetic Reactions Using Isoxazole Compounds

Choji Kashima*

*Department of Chemistry, University of Tsukuba, 1-1-1 Ten-nodai, Tsukuba-shi, Ibaraki, 305-8571, Japan

Abstract

The activation of C-5 methyl group of 3,5-dimethylisoxazoles is discussed by MINDO/2 calculation and H-D exchange reaction. The regioselective substitution reaction of 5-methylisoxazoles with electrophiles such as alkyl halides, carbon dioxide, carbonyl compounds, Schiff bases, nitriles, nitrites and nitroso compounds is reviewed. Also the conversions of resulting isoxazole derivatives to β-diketones, enones and some heterocyclic compounds are reviewed.