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Report | Regular issue | Vol 12, No. 12, 1979, pp.1567-1570
Published online, 1st January, 1970
DOI: 10.3987/R-1979-12-1567
General Synthesis of Octaalkylporphyrins

K. S. Chamberlin and E. LeGoff*

*Department of Chemistry, Michigan State University, East Lansing, MI 48824, U.S.A.


Reaction of the α,β-unsaturated ketone, 2a-f, with toluenesulfonyl methyl isocyanide give the 3-alkanoyl-4-alkyl pyrroles, 3a-f. Hydride reduction of 3a-f affords the 3,4-dialkylpyrroles 4a-f which condense with formaldehyde to give the 2,3,7,8,12,13,17,18-octaalkylporphyrins, 1a-f.