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■ Structure of Ephedradine C, a Hypotensive Principle of Ephedra Roots

Chohachi Konno, Mitsuru Tamada, Katsuya Endo, and Hiroshi Hikino*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

From the crude drug “mao-kon”, the roots of Ephedra plants, a novel macrocyclic spermine alkaloid ephedradine C exhibiting the hypotensive activity has been isolated whose stereostructure has been established as represented by formula I on the basis of chemical and physical evidence. Flexibility of the molecules of the ephedradines has been noticed by means of NMR and CD spectroscopy.