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Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Communication | Regular issue | Vol 14, No. 3, 1980, pp.295-298
Published online, 1st January, 1970■ Structure of Ephedradine C, a Hypotensive Principle of Ephedra Roots
Published online, 1st January, 1970
DOI: 10.3987/R-1980-03-0295
■ Structure of Ephedradine C, a Hypotensive Principle of Ephedra Roots
Chohachi Konno, Mitsuru Tamada, Katsuya Endo, and Hiroshi Hikino*
*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan
Abstract
From the crude drug “mao-kon”, the roots of Ephedra plants, a novel macrocyclic spermine alkaloid ephedradine C exhibiting the hypotensive activity has been isolated whose stereostructure has been established as represented by formula I on the basis of chemical and physical evidence. Flexibility of the molecules of the ephedradines has been noticed by means of NMR and CD spectroscopy.
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