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Communication | Regular issue | Vol 14, No. 7, 1980, pp.963-970
Published online, 1st January, 1970
DOI: 10.3987/R-1980-07-0963
Biotransformation of Isoquinoline Alkaloids with Rat Liver Microsomes

Tetsuji Kametani,* Naoaki Kanaya, Yohko Ohta, and Masataka Ihara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Optically active (+)-reticuline (1) was biotransformed into (-)-coreximine (2), (-)-scoulerine (3), (+)-isoboldine (4) and (-)-pallidine (5) with retention of the chirality by the incubation with rat liver microsomes. On the other hand, the racemate of reticuline formed the racemates of the above alkaloids on the some treatment. The S-adenosylmethionine was partially incorporated into the berberine bridge during the biotransformation of reticuline into the protoberberines.