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Communication | Regular issue | Vol 14, No. 12, 1980, pp.1939-1941
Published online, 1st January, 1970
DOI: 10.3987/R-1980-12-1939
A Simple General Method for the Acylation of Ethyl Indole-2-carboxylates

Yasuoki Murakami,* Masanobu Tani, Kenjiro Tanaka, and Yuusaku Yokoyama

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

Reaction of ethyl indole-2-carboxylates (1) with carboxylic acids in acetonitrile, using trifluoroacetic anhydride-phosphoric acid gave the ethyl 3-acylindole-2-carboxylates (2) in satisfactory yields. The present method provides a simple general method for acylation of ethyl indole-2-carboxylates.