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Review | Regular issue | Vol 14, No. 12, 1980, pp.2047-2091
Published online, 1st January, 1970
DOI: 10.3987/R-1980-12-2047
The Chemistry of the Acridizinium Ion

Sayeed-Din Saraf*

*Biochemistry Department, Kuwait University, Safat 13060, P.O. Box 5969, Kuwait


This paper reviews the various methods for the preparation of the acridizinium ion. One of the most successful method involved the use of cyclic acetal 2-(1,3-dioxolan-2-yl)pyridine (9), since the resulting intermediate obtained on treatment with benzyl bromide or substituted benzyl bromides are well suited for cyclisation in hot polyphosphoric acid. Acridizinium benzologs have also been prepared by replacement of the benzyl halides by naphthyl or phenanthrylmethyl halides or the pyridine carboxaldehyde by isoquinoline 1- or 3-carboxaldehydes. The properties, such as, oxidation, reduction, reaction with bases and electrophilic reagents are all discussed in detail.