Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 16, No. 4, 1981, pp.563-571
Published online, 1st January, 1970
DOI: 10.3987/R-1981-04-0563
Synthesis of 2-Amino-6-phenyl-4(3H)-pyrimidinone-1-oxide

Wendell Wierenga,* Harvey I. Skulnick, Robert L. Dow, and Constance G. Chidester

*Experimental Chemistry Researchm Physical and Analytical Chemistry Rresearch, The Upjohn Company, Kalamazoo, Michigan 49001, U.S.A.


Introduction of a 2,4-dichlorophenoxy group at the 4-position of 2-amino-6-phenylpyrimidine allowed a regioselective oxidation to the N1-oxide. The resultant pyrimidine oxide, derived from m-chloroperoxybenzoic acid treatment, was converted to the pyrimidinone by acidic hydrolysis. The structure was unambiguously determined by x-ray crystallographic analysis.