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Communication | Regular issue | Vol 16, No. 4, 1981, pp.577-580
Published online, 1st January, 1970
DOI: 10.3987/R-1981-04-0577
Reaction of 3-Aminocrotonamide with Nitriles

Tetsuzo Kato,* Takuo Chiba, and Makoto Sasaki

*Pharmaceutical Institute, Pharmaceutical Institute, Aobayama, Sendai 980-8578, Japan


The reaction of 3-aminocrotonamide (5) with some nitriles, such as acetonitrile, propiononitrile, iso-butyronitrile, and benzonitrile, gave the corresponding 2-substituted 6-methyl-4(3H)-pyrimidones (2a - 2d). Phenylacetonitrile reacted with (5) to give 2-benzyl-6-methyl-4(3H)-pyrimidone (7) and 6-amino-4-methyl-5-phenyl-2(1H)-pyridone (8a). Malononitrile, however, reacted with (5) to afford 6-amino-5-cyano-4-methyl-2(1H)-pyridone (8b).