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Report | Regular issue | Vol 16, No. 4, 1981, pp.609-611
Published online, 1st January, 1970
DOI: 10.3987/R-1981-04-0609
A New Synthesis of 1,4-Dihydro-3(2H)-isoquinolinones by the Cyclization of N-Hydroxymethylarylacetamides

Yasuo Watanabe,* Yasuko Komachi, and Tokumitsu Miyazaki

*Daiichi College of Pharmaceutical Sciences, 22-1 Tamagawa-cho, Minami-ku, Fukuoka 815-0037


A new and facile synthesis of 1,4-dihydro-3(2H)-isoquinolinones by the intramolecular amidomethylation with pyrophosphoric acid is described.