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Report | Regular issue | Vol 16, No. 4, 1981, pp.631-635
Published online, 1st January, 1970
DOI: 10.3987/R-1981-04-0631
Kinetics of Alkylation Reactions of Pyrrolizidine Alkaloid Derivatives

Joseph J. Karchesy and Max L. Deinzer*

*College of Veterinary Medicine, Oregon State University, Gilbert Hall 153, Corvallis Oregon 97331, U.S.A.


Comparison is made of the alkylating activities of a series of semi-synthetic pyrrole esters and pyrrole derivatives of pyrrolizidine alkaloids under pseudo-first-order reaction conditions. Examination of the rate data indicates two reaction patterns; those compounds whose rate data fit a simple first-order rate expression and a second group of compounds whose rate data fit a biexponential expression.