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Communication | Regular issue | Vol 16, No. 6, 1981, pp.973-977
Published online, 1st January, 1970
DOI: 10.3987/R-1981-06-0973
Total Synthesis of Prosophylline

Mitsutaka Natsume* and Masashi Ogawa

*Research Foundation Itsuu Laboratory, 2-28-10 Tamagawa, Setagaya-ku, Tokyo 158, Japan


The SnCl2-effected reaction of 4 with ethyl vinyl ether and 1-trimethylsilyloxybutadiene afforded 5a, 17, and 18. Prosophylline (1), a racemic alkaloid of Prosopis africana, was first synthesized by differentiating the double bonds of 17.