Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Regular issue | Vol 16, No. 8, 1981, pp.1291-1294
Published online, 1st January, 1970
DOI: 10.3987/R-1981-08-1291
Chiral Route to Some Alkaloids through Asymmetric Iodolactonization

Seiichi Takano,* Chikara Murakata, Yoko Imamura, Nobuhiko Tamura, and Kunio Ogasawara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan


Three chiral γ-lactone derivatives (1), (2), and (3), leading to chiral synthesis of three alkaloids, (-)-secopandoline (4), (-)-quebrachamine (5), and (+)-mesembrine (6), have been synthesized through the asymmetric iodolactonization of the amides (8) from the symmetric carboxylic acids (7) and the chiral amines.