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Communication | Regular issue | Vol 16, No. 11, 1981, pp.1901-1905
Published online, 1st January, 1970
DOI: 10.3987/R-1981-11-1901
Asymmetric Transformation of 2-Chloroalkanoic Acids via Oxazoline Derivatives

Saizo Shibata,* Hajime Matsushita, Hajime Kaneko, Masao Noguchi, Masahiko Saburi, and Sadao Yoshikawa

*Central Reseasrch Institute, Japan Tobacco Inc., 6-2, Umegaoka, Midori-ku, Yokohama, Kanagawa 227-8512, Japan

Abstract

Asymmetric transformation of 2-chloroalkanoic acids via oxazoline derivatives were examined using (S)-phenylalaninol as a chiral auxiliary. After the transformation optical purities of the acids were appreciably improved compared with those of the acids obtained before the transformation.