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Communication | Regular issue | Vol 16, No. 11, 1981, pp.1937-1946
Published online, 1st January, 1970
DOI: 10.3987/R-1981-11-1937
Studies on the Syntheses of Heterocyclic and Natural Compounds. Part 949. A Total Synthesis of (±)-Corynantheidol

Tetsuji Kametani,* Naoaki Kanaya, Toshio Honda, and Masataka Ihara

*Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

A facile synthesis of (±)-corynantheidol (17) has been achieved by the application of enamine annelation using 3,4-dihydro-1-methyl-β-carboline (5) and dimethyl 3-methoxyallylidenemalonate (6). Stereochemical assignment for catalytic hydrogenation products of the corresponding enamides has also been investigated.