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Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Report | Regular issue | Vol 16, No. 11, 1981, pp.1987-1992
Published online, 1st January, 1970■ Synthesis of 5-Hydroxy-3-methyl-3-pyrrolin-2-one [(±)-Jatropham, an Antitumor Alkaloid] and Its 4-Methyl Isomer
Published online, 1st January, 1970
DOI: 10.3987/R-1981-11-1987
■ Synthesis of 5-Hydroxy-3-methyl-3-pyrrolin-2-one [(±)-Jatropham, an Antitumor Alkaloid] and Its 4-Methyl Isomer
Tatsuo Nagasaka,* Sayuri Esumi, Naganori Ozawa, Yoshiyuki Kosugi, and Fumiko Hamaguchi
*School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Abstract
5-Hydroxy-3-methyl-3-pyrrolin-2-one (1), which is known as jatropham; an antitumor alkaloid, is conveniently synthesized from succinimide. One step synthesis of 5-hydroxy-4-methyl-3-pyrrolin-2-one (2) by the regioselective reduction of methylmaleimide with NaBH4/H+ is also described.
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