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Communication | Regular issue | Vol 19, No. 1, 1982, pp.11-13
Published online, 1st January, 1970
DOI: 10.3987/R-1982-01-0011
The Reaction of 2-Chloro-4-methylthioquinazolines with Alkylamines in Dimethylformamide

Hideki Miki and Junji Yamada

*Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan


The reaction of 2-chloro-4-methylthioquinazoline with alkylamines in dimethylformamide afforded 2,4-bis(methylthio)-, 2-alkylamino-4-methylthio-, 4-alkylamino-2-chloro-, 4-alkylamino-2-methylthio-, and 2,4-bis(alkylamino)quinazoline. The relative easiness of displacement of the chlorine and/or the methylthio group in 2-chloro-4-methylthioquinazoline depended on the bulkiness of alkylamines.