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■ A Simple Method for Introduction of Acyl Groups into Pyridine Nuclei via Trimethylstannyl-pyridines and -quinolines

Yutaka Yamamoto and Akihiko Yanagi

*Faculty of Pharmaceutical Sciences, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

Abstract

The 2-trimethylstannyl (TMSn) derivatives of pyridine and quinoline were directly treated with acyl chlorides to afford the corresponding 2-acyl-pyridines and -quinolines in good yields. On the other hand, replacement of the 3- and 4-TMSn groups by acyl groups was satisfactorily achieved by catalysis of palladium compound such as PdCl₂ or PdCI₂(PPh₃)₂.