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Report | Regular issue | Vol 19, No. 1, 1982, pp.83-87
Published online, 1st January, 1970
DOI: 10.3987/R-1982-01-0083
Novel Reactions via β-Carboline Intermediates

Seiichi Takano, Kozo Shishido, Yoko Imamura, and Kunio Ogasawara

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Novel reactions via some β-carboline intermediates have been described. Namely, the carboline(1a) gave the tetracyclic lactam(4a) when it was thermally condensed with the formyl ester(2), while its 9-methyl homologue(1b), on the same treatment, gave the 2-formylindole derivative(12). On the other hand, the carboline(13) yielded the tetracyclic lactam(16) when it was treated with butyryl chloride in the presence of triethylamine, whereas the carboline-acid chloride (18). prepared in situ from the amide-acid(17), took different course giving the 2-formylindole(23) on the same treatment.