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■ A General Synthesis of 5-(Alkylamino)-1-β-D-ribofuranosylimidazole-4-carboxamides

Taisuke Itaya, Tohru Saito, Tsunehiro Harada, Seiya Kagatani, and Tozo Fujii

*Faculty of Pharmaceutical Scicences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan

Abstract

Alkylation of N’-benzyloxy-5-formamido-1-β-D-ribofuranosylimidazole-4-carboxamidine (IV) in the presence of K₂CO₃ followed by hydrogenolysis of the N’-benzyloxy group and alkaline hydrolysis produced the title compounds (X), intermediates adaptable to the syntheses of various 3-alkyl-9-β-D-ribofuranosylpurines.