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Communication | Regular issue | Vol 19, No. 8, 1982, pp.1395-1398
Published online, 1st January, 1970
DOI: 10.3987/R-1982-08-1395
Highly Regioselective 1,4-Addition of 2-Lithio-2-(2,6-dimethylpiperidino)acetonitrile to α,β-Unsaturated Ketones

Takeshi Wakamatsu, Satoshi Hobara, and Yoshio Ban

*Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan

Abstract

2-Lithio-2-(2,6-dimethylpiperidino)acetonitrile, a formyl anion equivalent, readily reacts with α,β-unsaturated cyclic ketones to result in a successful conjugate 1,4-addition.