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Communication | Regular issue | Vol 19, No. 8, 1982, pp.1419-1426
Published online, 1st January, 1970
DOI: 10.3987/R-1982-08-1419
Heterocage Compound [1]. Synthesis of Oxacage Tricyclic Systems: Oxabrendane, Oxahomobrendane, Oxaisotwistane, Oxahomoisotwistane and Oxatwistbrendane Skeleton with an Amino Function

Shun Inokuma, Akihiko Sugie, Koichi Moriguchi, Hiromi Shimomura, and Junki Katsube

*Sumitomo Pharmaceuticals Research Center, 1-98, Kasugadenaka 3-chome, Konohana-ku, Osaka 554-0022, Japan

Abstract

A series of various oxacage tricyclic systems with versatile functional groups including an amino function were synthesized in order to examine their chemical, physicochemical and biological properties. The synthesis was based on the principle in which construction of the tricyclic systems was conducted by subjecting bicyclo[2.2.1]heptene or bicyclo[2.2.2]octene derivatives with an endo-hydroxyalkyl substituent to intramolecular cyclization.