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Report | Regular issue | Vol 19, No. 8, 1982, pp.1467-1471
Published online, 1st January, 1970
DOI: 10.3987/R-1982-08-1467
A Spontaneous Ring Closure Reaction as a New Route to Isoquinoline Derivatives

Ole Riis Anderesen and Erik B. Pedersen

*Department of Chemistry, Odense University, Campusvej 55 DK-5230 Odense M., Denmark

Abstract

A spontaneous reaction takes place between benzaldehydes, malononitrile and N-methyl-4-piperidone to yield the compounds 1a-i which can be aromatized to the new dicyano-1,2,3,4-tetrahydroisoquinolinamines 2a-e. Tetrahydro-2,7-naphthyridines 3a,b were also isolated as by-products.