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Report | Regular issue | Vol 19, No. 8, 1982, pp.1497-1500
Published online, 1st January, 1970
DOI: 10.3987/R-1982-08-1497
4-Substituted Azetidinones as Intermediates for Carbapenem Synthesis

Teruo Tanaka and Tetsuo Miyadera

*Chemical Research Laboratories and Analytical & Metabolic Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

Abstract

4-Iodomethylazetidin-2-one (1) was prepared by [2+2]cycloaddition reaction of allyl iodide with chlorosulfonyl isocyanate and utilized for the synthesis of 4-(thiazolin-2-yl)methylazetidin-2-one (3).