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Communication | Regular issue | Vol 19, No. 9, 1982, pp.1565-1569
Published online, 1st January, 1970
DOI: 10.3987/R-1982-09-1565
A Synthesis of N-(4’-Quinazolon-3’-yl)-2-pyridinecarboxamidines and Their Conversion into 1,2,4-Triazoles

Katsuhiko Nagahara and Atsushi Takada

*School of Pharmaceutical Sciences, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan


Treatment of N-(2’-aminobenzoyl)-2-pyridylamidrazone (1) with ethoxymethylenemalononitrile (EMMN) and ethyl ethoxymethylenecyanoacetate (EMCA) or ortho esters afforded the corresponding N-(2’-alkyl-4’-quinazolon-3’-yl)-2-pyridinecarboxamidines (2). Futhermore, treatment of 2 with ethanolic hydrochloric acid caused the ring transformation to give corresponding 5-alkyl-3-(2’-pyridyl)-1H-1,2,4-triazoles (3).