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Communication | Regular issue | Vol 19, No. 9, 1982, pp.1571-1574
Published online, 1st January, 1970
DOI: 10.3987/R-1982-09-1571
A Facile Syntheses of Thiazolidin-5-ones and Their Structural Assignment

Tadashi Okawara, Kentaro Nakayama, and Mitsuru Furukawa

*Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan


The reaction of 1,3-disubstituted thioureas(I) with α-haloacyl halides(II) was found to afford thiazolidin-5-ones(IV) in 5% sodium hydroxide-dichloromethane in the yields of 34-89%. The structures of IV were discussed in details.