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Communication | Regular issue | Vol 19, No. 9, 1982, pp.1597-1604
Published online, 1st January, 1970
DOI: 10.3987/R-1982-09-1597
Synthesis of New Oxapenams and Carbapenams

Kapa Prasad and Peter Stütz

*Sandoz Research Institute, A-1235 Vieena, Austria

Abstract

Diazoketones derived from 4-thioazetidinon-1-yl-acetic acids, on metal-catalysed decomposition, gave either carbapenams and/or oxapenams depending upon the nature of the substituent present on the thio function. Synthesis of a novel oxapenam carboxylic acid 16 which exhibited potent β-lactamase inhibitory properties comparable to clavulanic acid is described.