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Communication | Regular issue | Vol 19, No. 9, 1982, pp.1615-1617
Published online, 1st January, 1970
DOI: 10.3987/R-1982-09-1615
Structure of Arcapillin, an Antihepatotoxic Principle of Artemisia capillaris Herbs

Yoshinobu Kiso, Keiko Sasaki, Yoshiteru Oshima, and Hiroshi Hikino

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

In view of the observation that a methanol extract of Artemisia capillaris herbs has shown intense suppressive activity in carbon tetrachloride-induced liver lesion in mice, the extract has been fractionated by monitoring the hepatotoxic activity to furnish the known flavonol, eupatolitin (III), and a new flavone, arcapillin, as the liver-protective principles. The structure of arcapillin has been elucidated as that represented by formula I on the basis of chemical and physical data.