HETEROCYCLES

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■ Trichothecans — A Review

Chi Wi Ong

*University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, U.K.

Abstract

The trichothecanes are a family of polyoxygenated sesquiterpenes showing a number of interesting pharmacological properties, i) antibiotic, ii) antifungal, iii) antiviral, iv) insecticidal and v) cytotoxic and cytostatic activity, the most common examples being trichodermin and verrucarol. Recent trichothecanes synthesis have been reviewed, including our contribution in the total synthesis of 12,13-Epoxy-14-methoxy-trichothecene using dienyl-Fe(CO)₃ complexes.