HETEROCYCLES

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

■ Byproducts in the O-Phenyltetrazolylation of (±)-2,4-Dihydroxy-N-formylmorphinan-6-one. Alkylation at C-5

Fu-Lian Hsu, Kenner C. Rice, and Arnold Brossi

*Section of Medicinal Chemistry, Laboratory of Bioorganic Chrmistry, NIDDK, National Institute of Health, Bethesda, MD 20892, U.S.A.

Abstract

O-Alkylation of (±)-2,4-dihydroxy-N-formylmorphinan-6-one (4) with 5-chloro-1-phenyl-1H-tetrazole in DMF in the presence of potassium carbonate afforded substantial amounts of the C-5 alkylated ketones 6 and 7 in addition to the desired ketone 5. The structures of 5, 6 and 7 were supported by chemical correlation and on the basis of spectral data.