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Report | Regular issue | Vol 19, No. 12, 1982, pp.2313-2317
Published online, 1st January, 1970
DOI: 10.3987/R-1982-12-2313
Heterocyclic Quinones with Potential Antitumor Activity. A Convenient Synthesis of 5,6-Dimethyl-4,7-benzimidazolediones

Ippolito Antonini, Gloria Cristalli, Palmarisa Franchetti, Mario Grifantini, and Sante Martelli

*Department of Chemical Sciences, University of Camerino, Italy

Abstract

Simple syntheses of 1-substituted 5,6-dimethyl-4,7-benzimidazolediones (Ia-c) are described. The commercially available 5,6-dimethylbenzimidazole was alkylated and nitrated. The corresponding 4,7-dinitro derivatives were reduced to diamines and subsequently oxidized to quinones.