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Report | Regular issue | Vol 20, No. 1, 1983, pp.65-68
Published online, 1st January, 1970
DOI: 10.3987/R-1983-01-0065
The Stereochemistry and Conformation of the Diastereomers of Tetrahydrothiamin

Finian J. Leeper and Peter N. Lowe

*University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, U.K.


The major isomer of tetrahydrothiamin produced by NaBH4 reduction of thiamin is shown by 1H n.m.r. to be cis (5) and its conformation is predominantly (5a) which should be a major factor in the strong inhibition shown by its pyrophosphate (2) towards the pyruvate dehydrogenase complex af E.coli.