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Communication | Regular issue | Vol 20, No. 3, 1983, pp.397-400
Published online, 1st January, 1970
DOI: 10.3987/R-1983-03-0397
The Synthesis of Diphenyl Ethers Having Tyrosine Moiety

Tsutomu Inoue, Kenji Naitoh, Seiji Kosemura, Isao Umezawa, Thoru Sonobe, Nobuaki Serizawa, Noboru Mori, and Hideji Itokawa

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan


Dienone mono-epoxides (13) and (14) were readily reacted with potassium phenoxides to give intermediates (17) and (18) which were subjected to methylation followed by reduction with Zn/AcOH to give the desired diphenyl ethers (15a)-(15f) in good yield.