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Report | Regular issue | Vol 20, No. 5, 1983, pp.797-802
Published online, 1st January, 1970
DOI: 10.3987/R-1983-05-0797
One-Pot Acylation System Using Pyrazinethiols

Akihiro Ohta, Makoto Shimazaki, Naomichi Tanekura, and Sadayuki Hayashi

*Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

3,6-Dialkyl-2-pyrazinethiolcarboxylic esters, prepared from 3,6-dialkyl-2-pyrazinethiols, sodium and acyl chlorides in DME, were found to be convenient acylating reagents for amines and hydroxy compounds. Preparation of 3,6-dialkyl-2-pyrazinethiolcarboxylic esters and the following acylation were achieved in a one-pot system. The competition reaction on benzoylation showed that this one-pot system gave rise to the selectivity between acylations of amines, alcohols, and phenols.