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Report | Regular issue | Vol 20, No. 5, 1983, pp.839-843
Published online, 1st January, 1970
DOI: 10.3987/R-1983-05-0839
The Chemsitry of Drugs. III. Acid Hydrolysis of Antimalarial 5-Alkoxy-6,6-dimethyl-5,6-dihydro-s-triazines

Balbir S. Bajwa, Nancy Acton, and Arnold Brossi

*Natural Products Research Center, Department of Chemistry, University of New Brunswick, Bag Service #45222, Fredericton, New Brunswick, E3b 5A3, Canada

Abstract

5-Alkoxy-6,6-dimethyl-5,6-dihydro-s-triazines undergo a fragmentation reaction in refluxing 1N HCl. The hydrolytic degradation of the antimalarial WR 99210 belonging to this class of compounds was investigated.