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Communication | Regular issue | Vol 20, No. 6, 1983, pp.985-990
Published online, 1st January, 1970
DOI: 10.3987/R-1983-06-0985
5-Acetoxy-2-pyrrolidinone as a Precursor for N-Acylimminium Ion

Tatsuo Nagasaka, Masako Abe, Naganori Ozawa, Yoshiyuki Kosugi, and Fumiko Hamaguchi

*School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Abstract

Synthesis of 5-acetoxy-2-pyrrolidinone (3) and its reactions via N-acylimminium ion (6) with nucleophiles are described, especially in comparison with 5-alkoxy-2-pyrrolidinone (1) and 3-pyrrolin-2-one (4).