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Communication | Regular issue | Vol 20, No. 7, 1983, pp.1243-1246
Published online, 1st January, 1970
DOI: 10.3987/R-1983-07-1243
The Reactions of 4-Pyrimidinone Derivatives with Sodium Amide and with Hydrazine: Synthesis of Triazole

Yoshiro Hirai, Hiroyuki Egawa, Shoko Yamada, and Takao Yamazaki

*Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Toyama 930-0194, Japan

Abstract

The 3,6-dialkyl-2-isopropyl-4-pyrimidinones (1)-(3) and 3,6-dimethyl-2-phenyl-4-pyrimidinone (6) were converted to the N-dealkylated 4-pyrimidinones (4), (5), and (7) by reaction with sodium amide in liq. ammonia. Also, these 4-pyrimidinones (1)-(3) and (6) were converted to the triazoles (10)-(12) by heating with hydrazine, respectively.