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Report | Regular issue | Vol 20, No. 7, 1983, pp.1279-1284
Published online, 1st January, 1970
DOI: 10.3987/R-1983-07-1279
New Phthalazine- and Pyradazino[4,5-g]phthalazine Derivatives

Francesco De Sio, Stefano Chimichi, Rodolfo Nesi, and Lucia Cecchi

*CNR, Centro di Studio Sulla Chimica e la Struttura dei Composti Eterociclici e lolo Applicazioni, c/o Dipartimento di Chimica Organica “Ugo Schiff”, Università di Firenze, Via Gino Capponi 9, I-50121 Firenze, Italy


Some new phthalazine- and pyridazino[4,5-g]phthalazine derivatives have been prepared through diethyl phthalazine-6,7-dicarboxylate (5), obtained by regioselective reduction of the tetraester (1) with sodium aluminium hydride at - 50 °C, and treatment of the intermediate diformyl derivative (2) with hydrazine. The tautomeric behaviour of both 1,4-dihydroxypyridazino[4,5-g]phthalazine (13) and the N-methyl derivative (14) were also investigated by comparison of their spectroscopic properties with those of the model compounds (15) and (16).