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Communication | Regular issue | Vol 20, No. 11, 1983, pp.2177-2180
Published online, 1st January, 1970
DOI: 10.3987/R-1983-11-2177
A Simple Synthesis of 1,3-Dialkylpyrido[2,3-d]pyrimidines

Tsuneo Itoh, Toshihiko Imini, Haruo Ogura, Norio Kawahara, Takako Nakajima, and Kyoichi A. Watanabe

*School of Pharmaceutical Sciences, Kitasato University, 5-9-1, Shirokane, Minato-ku, Tokyo 108-8641, Japan


A novel and simplified synthesis of 1,3-dialkylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones from 6-allylamino- and 6-(substituted allyl)aminouracils by PdCl2-CuCl catalyzed oxidative cyclization is described.